Lack of epithelial PPARγ causes cystic adenomatoid malformations in mouse fetal lung
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چکیده
منابع مشابه
Cystic adenomatoid malformations are induced by localized FGF10 overexpression in fetal rat lung.
Fibroblast growth factor-10 (FGF10) is a mesenchymal growth factor, involved in epithelial and mesenchymal interactions during lung branching morphogenesis. In the present work, FGF10 overexpression was transiently induced in a temporally and spatially restricted manner, during the pseudoglandular or canalicular stages of rat lung development, by trans-uterine ultrasound-guided intraparenchymal...
متن کاملCongenital cystic adenomatoid malformation of the lung.
Ultrastructural study of a congenital cystic adenomatoid malformation of the lung revealed a persistence of type 2 pneumocytes lining the alveolar and gland-like spaces. The larger cystic areas were lined by normal bronchiolar-type epithelium and were surrounded by a few smooth muscle cells. The interstitium contained undifferentiated mesenchymal cells. No cartilage or bronchial glands were pre...
متن کاملCongenital Cystic Adenomatoid Malformation of the Lung
Congenital cystic adenomatous malformations (CCAMs) of the lung represent the most common lung defect diagnosed prenatally. CCAMs are intrapulmonary lesions with a typical hyperechoic appearance on ultrasound (US), with or without cystic components. Both sides of the lung, both sexes, and all races are equally affected. Most fetuses with CCAM are detected prenatally and have a good outcome, but...
متن کاملVideo-assisted thoracoscopic lobectomy for congenital cystic adenomatoid malformations.
Aim The aim was to show rare cases of congenital cystic adenomatoid malformation (CCAM) and the manner of its surgical treatment with video-assisted thoracoscopic surgery (VATS). Methods Two male and one female child, 7, 4 and 3 years of age were treated for symptoms of cough and high temperature in district hospitals. In all three children laboratory blood tests and chest radiography were done...
متن کاملMinimally invasive surgery for congenital cystic adenomatoid malformations - early experience
PURPOSE The aim of this study is to present our experience with minimally invasive surgery (MIS) for congenital cystic adenomatoid malformations (CCAMs). METHODS The medical records of infants under 2 years of age who underwent operation for a CCAM from 2009 to 2014 were retrospectively reviewed. RESULTS MIS (9 of thoracoscopy and 1 of laparoscopy) was performed for 10 infants (male:female ...
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 2017
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2017.07.113